Degenerative myelopathy in a Bernese Mountain Dog with a novel SOD1 missense mutation.
نویسندگان
چکیده
منابع مشابه
Breed Distribution of SOD1 Alleles Previously Associated with Canine Degenerative Myelopathy
BACKGROUND Previous reports associated 2 mutant SOD1 alleles (SOD1:c.118A and SOD1:c.52T) with degenerative myelopathy in 6 canine breeds. The distribution of these alleles in other breeds has not been reported. OBJECTIVE To describe the distribution of SOD1:c.118A and SOD1:c.52T in 222 breeds. ANIMALS DNA from 33,747 dogs was genotyped at SOD1:c.118, SOD1:c.52, or both. Spinal cord section...
متن کاملDegenerative myelopathy in a SOD1 compound heterozygous Bernese mountain dog.
S. Pfahler*, N. Bachmann, C. Fechler, C. Lempp, W. Baumg€ artner and O. Distl* *Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Buenteweg 17p, 30559, Hannover, Germany; Schweizer Sennenhund-Verein Deutschland e.V., H€ ulsenbrink 14, 31749 Auetal, Germany; Institute for Veterinary Pathology, University of Veterinary Medicine Hannover, Buenteweg 17, 30559, ...
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Canine degenerative myelopathy (DM) is a fatal neurodegenerative disease prevalent in several dog breeds. Typically, the initial progressive upper motor neuron spastic and general proprioceptive ataxia in the pelvic limbs occurs at 8 years of age or older. If euthanasia is delayed, the clinical signs will ascend, causing flaccid tetraparesis and other lower motor neuron signs. DNA samples from ...
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Canine degenerative myelopathy (DM) is a progressive disease process that is diagnosed late in life and mainly affects the pelvic limbs. Factors that make an ante-mortem definitive diagnosis of DM include: an insidious onset and clinical manifestation that mimics other disease processes of the pelvic limbs (hip dysplasia, cranial cruciate ligament rupture, etc.) or there may even be concurrent ...
متن کاملCanine degenerative myelopathy.
Canine degenerative myelopathy (DM) is an adult-onset fatal neurodegenerative disease that occurs in many breeds. The initial upper motor neuron spastic paraparesis and general proprioceptive ataxia in the pelvic limbs progress to a flaccid lower motor neuron tetraparesis. Recently, a missense mutation in the superoxide dismutase 1 (SOD1) gene was found to be a risk factor for DM, suggesting th...
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ورودعنوان ژورنال:
- Journal of veterinary internal medicine
دوره 25 5 شماره
صفحات -
تاریخ انتشار 2011